Divers Pharmacological Significance of Imidazole Derivatives-A Review

The imidazole nucleus has proven to be an unusually fertile source of medicinal agents. Imidazoles have become an important part of many pharmaceuticals. A wide category of drugs including antitumor, antifungal, cardioprotective, alpha-blocker, CNS-depressants, anticonvulsants, antiprotozoal and anthelmintics contain the imidazole derivatives with different substituent. The imidazole ring is a constituent of several important natural products including purine, histamine, histidine and nucleic acid. Imidazole drugs have broadened scope in remedying various dispositions in clinical medicines. Since its introduction into medicine, there have been more than 1000 compounds made in an effort to find others with more potent actions combined with less toxicity. Keeping in view the increasing importance of these derivatives, a need for the review is felt. The present article aims to review the research works which are carried out in terms of the development of imidazole derivatives of pharmacological relevance and the diverse pharmacological aspects of imidazole derivatives for anti-inflammatory, anti microbial, anti cancer, antidepressant, anticonvulsant and antihypertensive activities.