1Professor & Head, Dept of Pharma. Chem., N.G.S.M. Institute of Pharmaceutical Sciences, Paneer-575018, India
2Professor, Dept of Pharma. Chem., N.G.S.M. Institute of Pharmaceutical Sciences, Paneer-575018, India
Professor, Dept. of Pharma. Chem., NGSM Institute of Pharmaceutical Sciences, Paneer-575018, India
*Corresponding Author E-mail: jennifer_pharma@yahoo.co.in
Online published on 31 October, 2013.
The aim of the present study was to investigate anticonvulsant effect of ethanolic extract of the leaves of Sapindus trifoliatus on electrically and chemically induced seizures. The ethanol extract of the leaves of Sapindus trifoliatus (100, 200 and 400 mg/kg) were studied for its anticonvulsant effect on maximal electroshock induced seizures and metrazol (pentylenetetrazole) induced seizures in rats. Ethanolic extract of Sapindus trifoliatus (100,200 and 400 mg/kg) significantly reduced the duration of seizures induced by maximal electroshock (MES) as well as protected animals from metrazole induced tonic seizures.
Sapindus trifoliatus, antiepileptic activity, maximal electric shock, ethanol extract, Metrazol
