1Department of Biochemistry and Microbiology, Faculty of Pharmacy, Damascus University, Damascus, Syria
2Department of Physiology and Pharmacology, Faculty of Medicine, Damascus University, Damascus, Syria
*Corresponding Author E-mail: sorianasor@yahoo.com
Online published on 31 October, 2013.
We aim at exploring the probable association among obesity, leptin and insulin resistance in type 2 diabetes mellitus.126 patients (62 women and 64 men) with T2DM, and 74 healthy controls (42 women and 32 men). Type 2 diabetes mellitus patients were recruited from several medical centers in Damascus. Obesity factors (body mass index BMI, waist circumference, waist to hip ratio WHR), insulin resistance (HOMA-IR and fasting insulin), fasting Glucose and leptin were measured.
Serum leptin levels were significantly higher in type2 diabetic patient group in both sexes compared with control group, and positively correlated with body mass index, waist circumference, waist to hip ratio, HOMA-IR, insulin, in both sexes. Statistically, there was no significant correlation between serum leptin and glucose in both sexes.
Leptin, insulin resistance, obesity, type 2 diabetes mellitus
