Department of Chemistry, D. G. Ruparel College of Arts, Science and Commerce, Senapati Bapat Marg, Mahim (West), Mumbai 400 016, Maharashtra, India
*Corresponding Author E-mail: ssawant_s@yahoo.com
Online published on 27 November, 2013.
Simple and sensitive RP-HPLC methods are described for the determination of Olmesartan medoxomil. High-performance liquid chromatographic method was developed for the determination of Olmesartan medoxomil using Buffer: Acetonitrile (60:40, v/v) as the mobile phase and measuring the response at λmax 225 nm. The analysis was performed on a Kromasil C18 (150 X 4.6 mm), 5-μm column. The method was found to be accurate, with linearity ranging from 32 to 48 μ gm/ml for HPLC with a correlation coefficient (r2) 0.99979. Precision mean % assay was found to be 101.18% for HPLC. The mean % recovery was found to be 99.67% for HPLC
RP-HPLC, Olmesartan medoxomil, Tablet
