Formulation and In vitro Evaluation of Osmotic Drug Delivery System of Metoprolol Succinate

Controlled release delivery system provides a uniform concentration of drug at the absorption site and thus after absorption allow maintenance of plasma concentration within a therapeutic range, which minimizes side effects and also reduces the frequency of administration. An appropriately designed osmotically controlled oral drug delivery system (ODDS) can be a major breakthrough. Drug delivery from these systems is not influenced by the different physiological factors within the gut lumen. The main objective of this is to formulate ODDS for metaprolol Succinate that can provide prolonged effect and better patient compliance. Metaprolol is a β1-receptor blocking agent. ODDS formulations of metaprolol succinate were prepared using different concentrations of potassium chloride, by direct compression technique. The tablets were coated using coating pan with EC as semi permeable coating membrane. Stainless steel drill pins were used to make an orifice on the tablets. Tablet thickness, hardness, weight variation, drug content analysis and drug release study were performed. With increase in osmogen content and bore size, rate of drug release were found to be increasing an optimum concentration of osmogen and bore size to give a zero order release was identified.