Assessment of Guggul Gum as a Binding Agent in Tablet Formulations

Guggul gum has been evaluated as a binder for Pharmaceutical dosage forms. No significant work has been reported on guggul gum to use it as a tablet binder. Paracetamol granules were prepared by wet granulation technique. The binder concentrations used in the formulations were 2, 4, 6 and 8% w/w. the evaluation of granules showed 0.65 to 0.70 mm particle size, 28.15 to 29.16 º angle of repose. Tablets were prepared and its evaluation showed 1.3 to 0.9% friability, hardness about 7 kg/cm² 10 to 20 min disintegration time and more than 90% dissolution in 90 min. Tablet at 8% w/w binder concentration showed more optimum results as tablet binder. Guggul gum was found to be useful for the preparation of uncoated tablet dosage form.