1Department of Pharmaceutical Technology, BLDEA's College of Pharmacy, BLDE University Campus, Bijapur, Karnataka, India
2Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal, Karnataka, India
3Department of Pharmacology, Shri. B.M. Patil Medical College, BLDE University, Bijapur-586 103, Karnataka, India
*Corresponding Author E-mail: rvkulkarni75@yahoo.com
Online published on 31 October, 2013.
In the present study, an attempt was made to prepare and evaluate the natural polymers based compression coated tablets for controlled release of an antibiotic, cefadroxil monohydrate. The core tablets were prepared by direct compression method and compression coating granules were prepared by wet granulation method using sodium alginate and xanthan gum. The weight and drug content of all the tablets were found to be uniform. The hardness and friability were found within specified range. The core tablets released 99% drug within 1 h, while the compression coated tablets were capable of releasing the drug for 24 h. The coating formula containing more amount of aluminum chloride released the drug slowly as compared to barium chloride. Drug release mechanism was found to be non-Fickian transport type.
Compression coated tablets, cefadroxil monohydrate, controlled release, sodium alginate, xanthan gum
