Review on: Importance and Methods of Reduction of Water Solubility and Swelling of Natural Polysaccharide Polymer for Colon specific Drug Delivery System

Natural polysaccharides such as guar gum, Chitosan, pectin, chondroitin sulfate, dextran, are the good carrier for colon specific drug delivery system. These polymers having many advantages like biocompatible, biodegradable and safe. In addition, they have certain disadvantages such as water solubility and swelling in water in the upper GI tract when used for colon specific drug delivery system. Due to this premature release of the drug occur and 100% drug cannot reach to the colon. Therefore, the present review focuses on the different possible methods of reduction of water solubility and swelling of natural polysaccharide polymer and its importance.