Artificial Viral Envelops: A Novel Carrier in Gene Therapy

The use of plant viral vectors for the transient expression of heterologous proteins offers a useful tool for the largescale production of proteins of industrial importance, such as antibodies and vaccine antigens. In the recent years, advances have been made both in the development of first generation vectors (that empoly the ‘full virus’) and secondgeneration (‘deconstructed virus’) vectors. Artificial viral envelopes (AVE) are lipid vesicles which mimic with fusogenic envelop of retrovirus to utilize as target selectivity along with efficiency of delivery of viruses. The major component of AVE includes phosphatidylcholine, phosphatidyl serine along with sphingomyelins. The negative charge is present on AVE's help them for targeting the moieties such as viral binding proteins. The artificial viral envelopes show potential applications in plasmid delivery.