Formulation and Pharmaceutical Evaluation of Mucoadhesive Microsphere of Clarithromycin and Omeprazole

The objective of the present investigation was to formulate and evaluate the mucoadhesive microsphere of clarithromycin and omeprazole using hydroxyl propyl methyl cellulose K4M, hydroxyl propyl methyl cellulose K100M and carbopol 971p. Microspheres were prepared by non-aqueous emulsification solvent evaporation method using liquid paraffin as a cross linking agent. The prepared microspheres were evaluated for micromeritic properties such as particle size determination, bulk density, Carr's index, Hausner ratio and swelling ratio. Batches CF5 and OF5 showed the highest percentage yield i.e. 83.33% and 81.40% respectively. Likewise batches CF5 and OF5 also showed highest% drug entrapment i.e. 82% and 96.26% respectively. Batch CF5 showed 91.35% and OF5 showed 95.69% cumulative drug release in 8 hr of study. Finally, SEM and FT-IR analysis were done on optimized batches.