Antidiarrhoeal Mechanisms of Kutajarishta

Antidiarrhoeal effect of Kutajarishta, an ayurvedic formulation was evaluated with different agonist and antagonist in castor oil induced diarrhoea in mice. Antidiarrhoeal effect of Kutajarishta was decreased by Isosorbide dinitrite (nitric oxide donor) and Glibenclamide (potassium channel blocker). Yohimbine (α2 adrenergic receptor blocker) did not produce any significant effect on the antidiarrhoeal activity of Kutajarishta. The results obtained suggest that antidiarrhoeal effect of Kutajarishta was through potassium channels and nitric oxide pathway and not through α2 adrenergic receptors.