Development of Analytical Method for Simultaneous Estimation of Cefixime and Linezolid in Tablet Dosage Form

A simple, accurate, precise and sensitive UV spectrophotometric method is developed for simultaneous estimation of Cefixime and Linezolid in tablet dosage form. The method is based on the absorption ratio and wavelengths selected for analysis were 236.80 nm (λ_max of Cefixime) and 242.80 nm (iso-absorptive point) respectively. The linearity was obtained in the concentration range of 2–30 μg/ml for Cefixime and 2–30 μg/ml for Linezolid. The correlation coefficient of Cefixime and Linezolid were found to be 0.9992 and 0.9991 respectively. The proposed method was successfully applied for the simultaneous determination of both drugs in commercial tablet formulation. The method was validated for linearity, accuracy and precision as per ICH guidelines and hence can be used for the quantitative analysis of commercially available solid dosage form.