Formulation and Evaluation of Super Porous Hydrogel Composites of Metoprolol Tartrate

The purpose of this study was to develop formulations and systematically evaluate in vitro performances of super porous hydrogel composites of Metoprolol Tartrate. A cross-over design was employed in formulating the SPHC with variation in polymer concentration (N, N-methylene-bisacrylamide (1–3%) and Ac-Di-Sol (200-300mg)). Study the effect of variation on swelling time, mechanical properties and in vitro drug release. The result shows that increase in Ac-Di-Sol concentration also increase in mechanical strength where as 2% of Bis concentration have less swelling time. In-vitro release data show that best result at optimum concentration of Bis (2%) and Ac-Di-Sol concentration (250mg).