Formulation and Evaluation of Orally Disintegrating Tablet of Atenolol by Using Ion Exchange Resin

The present research deals with study of flow properties of Atenolol along with excipients and formulate into orally disintegrating tablets (ODT's). Formulation of atenolol into an ODT can provide fast relief with higher bioavailability. Conventional tablets of atenolol are available in the market but as it is used in life threatning conditions like angina pectoris, hypertension in which quick action is required. ODT is desired for Patients who have difficulty in swallowing or chewing solid dosage forms. The present work describes the excipients selected shows better flow properties as compared to drug alone. The prepared fast disintegrating tablets were evaluated for weight variation, content uniformity, hardness, disintegration time, wetting time and friability of tablets. Indion-234 shows faster disintegrating action. Faster disintegration may show increased bioavailability and onset of action. Among the three promising formulations, the formulation F6 emerged as the overall best formulation based on the in-vitro drug release characteristics.

The ODT developed in this work will hopefully contribute to improve acceptability. As a result, ODT administration of Atenolol may appear to be a promising alternative drug delivery to conventional drug delivery.