Formulation and Evaluation of Gastroretentive Drug Delivery System of Cefixime Trihydrate

The study was aimed at preparing an expandable gastroretentive drug delivery system for the model drug cefixime trihydrate, and evaluating the various parameters including the buyouncy studies, in vitro drug release and expansion properties of tablet. 9 formulations (F1 to F9) were prepared by direct compression by employing 32 factorial design by varying concentration of two hydrophilic polymer viz. HPMC and sodium CMC. Formulation F5 showed maximum swelling index at 6hrs and 12 hrs and gave slow and maximum drug release up to 12 hrs and showed good expansion (diameter) increased up to 15–16 mm which didn't pass through the pylorus.