Liquisolid Technique a Novel Approach to Enhance Solubility and Dissolution Rate: A Review

The term “liquisolid medication” implies oily liquid drugs and solutions or suspensions of water insoluble drugs carried in suitable non-volatile solvent systems. Liquisolid compacts demonstrated a significantly higher drug dissolution rates than those of conventionally made capsules and directly compressed tablets. This was due to the increased wetting properties and surface of drug available for dissolution. This review paper highlights the application of liquisolid technique to enhance the solubility and dissolution of water insoluble drugs. This technique is appropriate for poorly or water insoluble drugs and also for immediate or sustained release formulations. Design of this technique was according to new mathematical model proposed by Spireaset al.