Multiple Unit Particle System (MUPS): Novel technology for preparation of Extended Release (ER) tablets

Compressed multiple unit pellet tablets/multiple unit particulate or pellet systemsare commonly called as Multiple Unit Particulate Systems (MUPS). MUPSare composed of polymer coated subunits namely pellets; which are embedded in an inert excipients matrix designed to overcome the difficulties in administering capsules and for improved physicochemical stability compared to suspensions. The functional coating like drug coating, barrier coating, enteric polymer coating is usually applied in a fluid bed coating processor that provides each subunit with the characteristic desired drug release properties. The size, shape and surface morphology of the pellets to be coated are the criterions for coating of pellets. Design of MUPS involves formulating pellets by different techniques and further compression of these pellets into rapidly disintegrating tablets; disintegrate rapidly in the oral cavity for the delivery of coated pellets into the gastrointestinal tract or at the site of release of the drug. That's why MUPS is a new trend in formulation industry to deliver the drug of categories like Antacid, Non-steroidal anti-inflammatory drugs (NSAIDs), Colon specific drugs etc. In spite of the challenges like content uniformity of the compressed tablets, ability of the film to withstand compression force; MUPS occupy a prominent role in formulating drugs due to their improved patient compliance, process feasibility and therapeutic advantages.