Evaluation for CNS Activities of Hexane Extract of Citrullus lanatus Seeds

The present study aimed to evaluate the possible CNS activities of hexane extracts of Citrullus lanatus Seeds. The effect of hexane extracts of Citrullus lanatus Seeds was tested for Anti-depressant activity using Forced Swim Test (FST) and Tail Suspension Test (TST) in mice, Anxiolytic activity using Elevated Plus Maze(EPM) and Dark-light model in mice and effect on motor co-ordination and skeletal muscle using Rota-Rod, Grip Strength test in mice. The hexane extract exhibited significant anti-depressant and anxiolytic activities but the extract does not produces skeletal muscle relaxant activity beside it slightly improved the skeletal muscle activity in animal models. It can conclude that hexane extract of Citrullus lanatus Seeds possess anti-depressant and anxiolytic activity but does not affect on skeletal muscle activity. Finally, it can say that this can be used in CNS disorders like depression and anxiety and does not affect of skeletal muscle activity like synthetic drugs.