Department of Chemistry, D. G. Ruparel College, Mahim, Mumbai, Maharashtra, India
*Corresponding Author E-mail:
Online published on 31 October, 2013.
A simple, rapid and sensitive RP-HPLC method developed for quantitative determination of an angina pectoris drug i.e. 2,3,4-Trimetazidine Dihydrochloride and its three related substances using C18 150 X 4.6, 5um column and mobile phase consisting of aqueous buffer and Methanol. This method was validated as per ICH guideline for parameters including specificity, precision, linearity, accuracy, limit of detection and limit of quantization. The method was found to be stability –indicating and useful for analysis of drug's related substances.
