Formulation and Evaluation of Nizatidine Floating Tablets by using Natural, Semisynthetic and Synthetic Polymers

The objective of the present study is to formulation and evaluation of the floating drug delivery system of Nizatidine. Floating tablets of Nizatidine (150mg) were formulated by employing HPMC K100M, Chitosan and Carbopol940 as matrix former at 50% strength, sodium bicarbonate and calcium carbonate at 15% and 10% strength as gas generating agent respectively. The polymers Carbopol940 and Chitosan were combined with HPMCK100M in different ratios to control release rate of drug. The drug-excipient compatibility, pre and post compression parameters, buoyancy properties and swelling index were evaluated. The results of the in vitro release studies showed that the matrix polymer HPMCK100M (HF) release the drug more controlled manner than Chitosan and Carbopol940. The formulation NF5 (Chitosan: HPMC-20:80%) release the drug similar to HF. The formulations (SF4, SF5) containing combination of HPMCK100M and Carbopol940 release the drug more controlled manner than HF.