Formulation and In-vitro Evaluation of Oro Dispersible Tablet using phenylephrine Hydrochloride as model drug

The objective of the study is to develop phenylephrine orally disintegrating tablet using different super disintegrants which would disintegrate tablet rapidly in oral cavity.12 batches of phenylephrine orally disintegrating tablet was prepared by direct compression method using cross povidone, cross carmellose sodium, low substituted hydroxypropyl cellulose and sodium starch glycolate as disintegrants in different concentrations. The developed oral disintegrating tablets were evaluated for different physical chemical evaluations like drug content, hardness, friability, weight variation, wetting time, invitro dispersion time, In vitro disintegration time etc. All formulations had shown the results within the prescribed limits. The In vitro drug release study indicated faster and maximum drug release from formulations F-12.