Malla Reddy College of Pharmacy, Maisammaguda, Secunderabad, Andhra Pradesh, India
*Corresponding Author E-mail: vijayasree_2002@yahoo.co.in
Online published on 29 November, 2014.
To evaluate the binding efficacy of the Pisum sativum seed powder in lornoxicam tablet formulation in comparison with standard binder such as acacia. Different concentrations of Pisum sativum seed powder were used as binder for the formulations of lornoxicam tablets.
The tablets were prepared by direct compression method and evaluated for volume of tablet, packing fraction, tensile strength, content uniformity, hardness, disintegration time and in-vitro dissolution studies.
The result suggests that formulations containing the concentration of 13.3% Pisum sativum seed powder as binding agent show short disintegration, fast dissolution to produce a tablet of better mechanical strength.
Optimized formulation was subjected to stability studies at 40° and 75% RH showed no change in hardness, disintegration time and in vitro drug release at 3 months.
Lornoxicam, Pisum sativum seed powder, acacia, binding efficiency
