Comparative Evaluation of Artemisia nilagirica (Clarke) on Experimental CNS Models

The plant Artemisia nilagirica (Clarke) was found to be used by different traditional systems and folklore for the treatment of various disorders. The aim of the present study is to investigate the effect on central nervous system (CNS) of the ethanol extract of Artemisia nilagirica (Clarke) plant in Swiss albino mice and Wistar rats. The CNS effects were evaluated by general behaviour, exploratory behaviour, Muscle relaxant activity and Phenobarbitone sodium-induced sleeping time using standard procedures in experimental animal models the results revealed that the ethanol extract at 100 and 200mg/kg caused a significant reduction in the spontaneous activity (general behavioural profile). Exploratory behaviour pattern (Y-maze and head dip test). Muscle relaxant activity (rotarod and traction test), and significantly potentiated phenobarbitone sodium-induced sleeping time. The results conclude that the extract exhibit CNS depressant activity in tested animal models.