The Role of Leptin on Obesity: A Review

Leptin is an adipose tissue hormone that helps in regulating energy intake and energy expenditure, including appetite and metabolism. Resistance to appetite suppressing effects of leptin is associated with obesity. Here, we review the mechanism of intracellular signal and role of these signals in action of leptin and further we deeply discuss about leptin resistance in causing obesity and a specifically focusing on the failure of the brain to sense leptin hormone which leads to obesity. It has been discussed deeply about leptin's mechanism action in regulating the body weight.