Evaluation of effect of Piper betel, Centella asiatica and Aristolochia indica extracts on bacterial enzymes in 1, 2-dimethyl hydrazine induced colon cancer in wistar rats

The colon enzymes play a very important role in colon carcinogenesis. The different enzymes were initially reported in low compared to high risk colon cancer groups. In the present study the effect of Piper betel, Centella asiatica and Aristolochia indica extracts has been studied on 1, 2-dimethylhydrazine induced colon cancer in wistar rat. A total of 42 rats were randomized into seven groups. Administration of aqueous and alcoholic extracts of Piper betel 200mg/kg b.wt, and alcoholic extracts of Centella asiatica 200mg/kg b.wt and Aristolochia indica 200mg/kg b.wt lowered the activities of colon and fecal bio-transforming enzymes. Results suggest that these extracts may be possible chemopreventive agents against colon cancer.