Antihyperglycemic, Hypoglycemic and Cytotoxic Activity of Albizia lebbek and Trigonella corniculata

Antihyperglycemic, hypoglycemic and cytotoxic activities of methanolic extract of Albizia lebbeck and Trigonella corniculata were studied. Hypoglycemic action of plants was investigated using normoglycemic rabbits (acute study only), whereas antihyperglycemic activity was studied using alloxan induced diabetic rabbits (acute and chronic study). Results revealed both plant extracts and their mixture having significant anti diabetic potential at dose of 200mg/kg comparable to standard drug Glibenclamide (0.5 mg/kg). Brine shrimp assay was used for the determination of cytotoxicity and results showed plants to have low toxic potential (LD50>1000 μg). The study conducted proves both plants and their mixture to have high potential for the treatment of diabetes.