1Department of Pharmaceutics, Gourishankar Institute of Pharmaceutical Education and Research, Limb, Satara, Maharashtra, India
2Department of Pharmaceutics, Tatyasaheb Kore College of Pharmacy, Warananagar, Kolhapur, Maharashtra, India
*Corresponding Author E-mail: nsalunkhe7500@gmail.com
Online published on 29 May, 2014.
Solid dispersions of terbinafine HCl were prepared with polxamer 188 using melt granulation technique. Three formulations were prepared by using three different ratios of drug and polymer. The prepared formulations were subjected to solubility and dissolution tests. Moreover they were characterized by X-ray powder diffractometry (XRPD) and Fourier Transformation Infra-red Spectroscopy (FTIR). The characterization studies depicted better physical interaction among drug and polymer with no chemical interaction. Further it was clearly observed that there was significant rise in solubility and dissolution properties due to decrease in crystallinity. Thus solid dispersion could be best solution to improve physicochemical properties of terbinafine HCl.
Terbinafine HCl, polxamer 188, solid dispersion, dissolution properties, physicochemical properties
