D-Pinitol Prevents Rat Colon Carcinogenesis Induced by Azoxymethane through Free Radical Formation Induced Cell Damage and Affects Enzymes and Antioxidants

Anyone can develop cancer. Since the risk of being diagnosed with cancer increases with age, most cases occur in adults who are middle aged or older. About 77% of all cancers are diagnosed in persons 55 years of age and older. Cancer researchers use the word “risk” in different ways, most commonly expressing risk as lifetime risk or relative risk. Azoxymethane (AOM) acts as a potent site and organ specific carcinogen by generating various reactive metabolic intermediates leading to oxidative stress. Female Sprague Dawley rats were divided into four groups and each group consisting of six animals. Group I and group IV were vector and drug control. The group II and group III animals were treated with AOM 12 mg/kg bodyweight to induce colon carcinoma. Rats received cancer bearing Group III animals were treated with D-Pinitol at the concentration of 300 mg/kg bodyweight for 45 days orally. At the end of the experimental period all the rats were sacrificed. The colon and liver tissues levels of the enzymic and non-enzymic antioxidants were significantly decreased in cancer bearing animals when compared to the control animals. Lipid peroxide levels (LPO) were estimated. From our results, we conclude that D-Pinitol is a potent antioxidant and play a protective role against AOM induced colon cancer.