Formulation and In vitro Evaluation of Gastroretentive Floating Tablets of Ivabradine Hydrochloride using Different Polymers.

The study was aimed on preparing gastro retentive floating tablets with Ivabradine HCl using different polymers such as HPMC K 100 and Xanthan gum. Sodium bicarbonate and citric acid were used as gas generating agents. Tablets was prepared by direct compression methodand subjected to various evaluation parameters like hardness, thickness, friability, weight variation, drug content uniformity, floating lag time, floating duration time, invitro release studies. Release kinetics was explained with zero order, first order, Higuchi and Peppas kinetics. The optimized formulation was F8 and it showed an invitro drug release of 99.84% at the end of 8^th hour, following Peppas kinetics for the release.