Evaluation of Stability Parameters for Calcium Carbonate Antacid Suspension using Different Concentrations of Suspending Agents

Calcium carbonate is non-systemic antacid and its reaction with HCl in the stomach is not as rapid for this reason it produces a more prolong reduction in gastric acidity. Present work is to establish a method to prepare a stable antacid suspension using different suspending agent, the suspending agents are essential for better stability of a suspension. Hence, an attempt is made to identify the suitable suspending agent and its optimum concentration for antacid formulation. Gelatin, Tragacanth, Guar gum, Acacia and Bentonite have been studied at different concentrations. Observations depict that suspension using acacia as suspending agent shows flow rate 1.25, 1 and 0.83 ml/sec, viscosity 1.25, 1.40 and 1.59 poise, pH 6, 7 and 7, and sedimentation volume 0.06, 0.1 and 0.2 for the concentrations 1%,1.5% and 2% respectively. Observation of these stability parameters shows that acacia is a better suspending agent in comparison to other as it gives minimum degree of flocculation and sedimentation volume in comparison to other at the optimum concentration that is 2% concentration.