1Department of Pharmaceutical Analysis, Priyadarshini College of Pharmaceutical Sciences, Chowdaryguda (V), Ghatkesar (M), Hyderabad, AP
2Department of Pharmaceutical Chemistry, Holy Mary Institute of Pharmacy, Bogaram (V), Keesara (M). Hyderabad, AP
3Department of Pharmaceutics, Holy Mary Institute of Pharmacy, Bogaram (V), Keesara (M), Hyderabad, AP
*Corresponding Author E-mail: manalasowmya@gmail.com
Online published on 22 October, 2014.
The present research work discusses the development of a UV estimation method for Bicalutamide. A simple, accurate, rapid, sensitive and precise UV spectrophotometric method has been developed for the estimation of Bicalutamide in pure and pharmaceutical dosage forms. Beer's law was obeyed in the range of 2.5–15 μg/ml at 272nm and shows a correlation coefficient of 0.999. The concentrations of this drug were evaluated in laboratory mixture and marketed formulation. Accuracy was determined by recovery studies from tablet dosage form and ranges from 99.6 to 100.2%. Precision of present method was find out as repeatability, day to day and shows the values within acceptable limit (R.S.D ≤ 2 percentage).
Bicalutamide, UV spectrophotometer, Validation, Beer's law
