Spectrum of Antimicrobial Susceptibility of E. coli and Staphylococcus aureus Isolates from Clinical Samples

Background and objectives: Resistance of antibiotics is increasing the public health threat and serious clinical problems in treatment. Aim: To determine the antibiogram of E.coli and Staphylococcus aureus isolates and to discuss sensitivity and resistance pattern. Methodology: The Kirby Bauer method was used to evaluate the susceptibility of 120 isolates each of E.coli and Staphylococcus aureus to various antibiotic drugs on Mueller-Hinton agar. Results: The prevalence of multiple drug resistance as determined on Mueller Hinton agar was 87.8% for E.coli and 90.55% for Staphylococcus aureus. For E.coli, resistance ranged from 7.5% (gentamicin and amikacin) to 89.16% (cotrimoxazole, ampicillin). In the case of Staphylococcus aureus resistance ranged from 15.83% (erythromycin and gentamicin) to 94.16% (penicillin). Conclusion: High levels of resistance seen in this present study. And an attempt was done to find out the most resistant antibacterial drug for routine infections.