Design and synthesis of thiazol derivatives with biological evaluations as antitumor agents

The synthesis of 2-cyanomethyl-thiazole-4-one (1) was obtained via the reaction of malononitrile with thioglycolic acid, then the formed product was directed toward the reaction with either acetoacetanlide or 4 chloro acetoacetanlide to produce compounds 2, 3. The latter compounds were reacted with either aromatic aldehyde or diazonium chloride derivatives to produce compounds 10, 11, 16–21 and 28–33. Finally compound 14 and 15 were obtained through the reaction of compound 10 with either malononitrile or ethylcyanoacetate. The newly synthesized compounds were evaluated for antitumor activity.