In Vitro Cytotoxicity Studies of Pamam Dendrimer with an Antifungal Agent

PAMAM dendrimer offers an ideal carrier for drug delivery that has the capacity to attach and discharge drugs by numerous ways. In this research work, we explored the potential of polyamidoamine dendrimers (PAMAM) as a carrier for ketoconazole and in vitro evaluation of ketoconazole-PAMAM complexes. Cytotoxicity studies were carried in J774A, mouse macrophage cell lines. Our research work revealed that binding of drug into dendrimers led to sustained release of ketoconazole in vitro. Results of the cytotoxicity studies also showed that the complexation of drugs with PAMAM dendrimer leads to the reduction in cytotoxicity of drugs.