Detection of carbapenemase resistance among clinical isolates of Klebsiella pneumoniae

Carbapenems are considered to be the choice for the therapeutic management of multidrug resistant gramnegative bacterial infections. Currently, the spread of carbapenem-resistant bacteria are in alarming state due to the limited choice in antibiotics for treating infections caused by them. We detected the antibiotic susceptibility pattern using most routinely used antibiotics and found higher percentage resistance pattern and also checked for the presence of carbapenemase in our isolates by Modified Hodge test method and we found there were no isolates found to be positive for carbapenemase production. We conclude that more number of isolates needs to be screened for the presence of such resistance mechanism to validate the actual resistance status and prompt treatment.