Synthesis and biological evaluation of some novel pyrazoline incorporated 2-quinolones

A series of novel substituted 1-amino-3-(5-phenyl-4, 5-dihydro-1H-pyrazol-3-yl)quinolin-2(1H)-one (AJP1-AJP8) have been synthesized upon reaction with 1-amino-3-cinnamoyl-quinolin-2(1H)-one using hydrazine hydrate as cyclising agent in alcohol medium. 1-amino-3-cinnamoyl-quinolin-2(1H)-one were synthesized by condensing 3-acetyl-1-amino-quinolin-2-one with different substituted benzaldehyde in presence of ethanolic KOH. The structures of the final synthesized compounds were characterized by IR, ¹H NMR and mass spectra. The final synthesized compounds were screened for their antioxidant activity by DPPH radical scavenging method and in vitro cytotoxic activity against Ehrlich Ascites Carcinoma cells (EAC) by Trypan blue exclusion method.