Research Journal of Pharmacy and Technology

Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory disorder. Females are highly affected by the ill effect of arthritis due to misbalancing of sex hormone. Macrophages, T cells and B cells infiltrate the synovium that lines the joints, while the synovial fluid is dominated by neutrophils. Chronic inflammation leads to destruction of joint cartilage and bone. Several research findings indicate the involvement of sex hormones in RA. B cells and T cells promotes pathogenesis of arthritis. Marked pathogenesis of arthritis is dominant in female compared to male. Active involvement of T cells and B cells produces proinflammatory cytokines observed.