Statins: Pleiotropic Effect

Statins are most effective in reducing the plasma cholesterol level by inhibiting hydroxyl methyl glutaryl coenzyme A reductase. Emerging evidence suggest that statins exert other mechanism of action called Pleiotropic effects; which are plaque stability, endothelial function modification, thrombus formation etc. Therefore therapeutic potential of statins extends beyond lipid lowering. Correctly underlying these pleiotropic effect suggest a new method to prevent and treat wide variety of life threatening disorders. Thus statins has added a wide scope of potential targets ranging from acute coronary syndrome to other renal infections and neuroleptic disorders.