Significance of Jobs Plot in Cyclodextrin Complexation

Jobs plot or continuous variation method is used to estimate the stoichiometry in cyclodextrin complexation. Cyclodextrin complexation is well known as widely acceptable technique for improving the poor physicchemical properties of BCS class II and class IV drugs. The stoichiometry of the inclusion complex is given by the number of guest and host molecules present in the supramolecular complex/inclusion system. The most common stoichiometry is 1: 1, implying the inclusion of a single guest molecule. Now-a-days jobs plot is replaced by phase-solubility study. Jobs plot deals with spectral methods mainly for molecular modelling study of drugs and bioactives.