Research Journal of Science and Technology

Rivaroxaban is oxazolidine derivatives having anticoagulant activity. In literature few analytical methods are discussed for the estimation of Rivaroxaban. The objective of this study is to develop and validate RP-HPLC method for the qualitative estimation of the drug. In most of the methods, the isocratic elution was carried out by using Acetonitrile, water and buffer as a mobile phase. The wavelength was in between 245 to 252 nm. The flow rate was approximately 1.0 ml/min. the temperature set was ambient temperature. The developed methods were validated as per ICH guidelines and this methods were found to be specific, precise, sensitive and robustness.