In vitro anticancer activity of Majidea zanquebarica J. Krik. ex Oliv. (Sapindaceae)

The present study was designed to evaluate the in vitro cytotoxicity activity of hexane, 70% methanolic extract and bark hexane extract of M. zanquebarica. In this study the extract was tested using Human cancer cell lines, such as PC-3 (Prostate carcinoma), A-431 (Epidermoid carcinoma), HeLa (Human cervical carcinoma) and MCF (Breast cancer) for their effects on cell viability, growth inhibition and cell morphology. Cell viability and inhibition were determined by MTT [(3,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide)] assay. Hexane bark extract had shown more percentage of inhibition on A431 cell lines. Out of the different concentrations used, the hexane extract showed IC₅₀ value of 100 μg/ml concentration in all the cell lines. The result implicated that hexane extract was more pronounced with more activity against all the cancer cell lines.