Synthesis of some novel benzimidazole-oxothiazolidine derivatives as anti-tubercular agents: Conventional vs microwave assisted approach

N-(4-alkyl-4-oxo-1,3-thiazolidin-3-yl)-2-(5-nitro-1H-benzimidazole-1-yl)acetamide derivatives were designed and synthesis. Twelve novel derivatives were synthesized using conventional approach and Microwave-assisted synthesis. Herein we report the comparisonbetween the two approaches in terms of time, solvents used and yield. As evident from the results obtained the green chemistry approach for the synthesis is the more efficient way of synthesis in terms of time and yield. The synthesized compounds were subjected to anti tubercular Alamar Blue Assay. Some of them have shown promising activity.