Characterization of Polyelectrolyte Complexes containing Chitosan/ Polyanions and study of its Release efficacy for Colonic Delivery of Ibuprofen

Chitosan microparticles hydrogels of ibuprofen have been prepared and evaluated using a multiparticulate method that combines particular biodegradability with pH-sensitive properties. The ionotropic gelation method was used in the current study to successfully construct the Cs-polyanion (HGA, LGA, HMP, and LMP) hydrogel complexes at different ratios (10%, 30%, 50%, 70%, and 90% of Cs) in acetate buffer 0.05 M, 4.3pH. PEC were assessed for in vitro drug release in simulated gastrointestinal fluid, surface shape, particle size distribution, and % drug entrapment. In a pH progression medium that replicates the state of the gastrointestinal tract, the PEC hydrogels maintained the release for eight hours. The drug release data was subjected to Higuchi, first-order, and zero-order mathematical drug release models. For every sample, the drug release kinetic parameters showed the strongest association with the first order. The current study concludes that chitosan polyanion microparticles are promising controlled release delivery vehicles for ibuprofen that can also be directed to the colon.