Review on Alzheimer-Suppressing Potential of different Medicinal plant

Progressive neurodegenerative disorder i.e. Alzheimer’s disease (AD) is characterized by cognitive decline, oxidative stress, and cholinergic dysfunction, β-amyloid aggregation, tau hyperphosphorylation. Plant-derived neuroprotective agents have gained increasing scientific attention due to their multi-target mechanisms and favorable safety profiles. This review aims to highlight the Alzheimer’s-suppressing potential of four traditionally important medicinal plants: Convolvulus pluricaulis, Curcuma longa, Withania somnifera, and Bacopa monnieri. C. pluricaulis has been reported to exhibit nootropic and anxiolytic effects mainly via cholinesterase inhibition and antioxidant activity. C. longa (Curcumin) has strong anti-amyloid, anti-inflammatory, and metal-chelating properties, offering protection against plaque formation and neuronal toxicity. W. somnifera (Withanolide) promotes synaptic regeneration, decreases oxidative stress, and provides amyloid and tau pathology modulation. B. monnieri, rich in bacosides and flavonoids, enhances cognitive performance by reducing oxidative damage, improving cholinergic function, and inhibiting β-amyloid aggregation. Altogether, these botanicals act through complementary pathways, including antioxidant defense, anti-inflammatory modulation, neurotransmitter regulation, and prevention of amyloid/tau pathology, thereby making them promising candidates for the integrative management of AD. Further clinical validation is essential to determine standardized doses and the long-term efficacy of these extracts, as well as synergistic potential in combination therapies.