Central Forensic Science Laboratory, Plot No 2, Sector 36 A, Dakshin Marg, Ministry of Home Affairs, Govt. of India, Chandigarh, India-160036
*Corresponding Author E-mail: atulbajaj37@gmail.com
Online published on 12 June, 2018.
The present work describes a method for simultaneous determination of four p-hydroxy benzoates (parabens) preservatives in cosmetics, personal care and pharmaceuticals formulations. The method blends liquid-liquid extraction and gas chromatography mass spectrometry in electron impact ionization positive mode. The various influencing parameters were optimized and validated. Chromatographic separation was achieved on BP-5 capillary column with short run time of 8.13 minutes. Linearity of the method was excellent for all analytes with regression coefficient values (R2) > 0.993. The method was successfully applied to commercially available formulations. The developed method can be used in routine every day analysis by testing and quality control laboratories.
Cosmetics, pharmaceuticals, personal care products, Parabens, GC-MS, preservatives
