Formulation development and evaluation of antifungal topical cream of itraconazole

The current study was to formulate and evaluate itraconazole topical cream for fungal infection.

Two antimicrobial preservatives used for formulation of itraconazole creams, namely, methyl paraben, and propyl paraben. Creams were formulated by the trituration method. Each formulation containing five different formulations of different concentrations of ingredients.

All the prepared formulation was evaluated successfully. Out of all the formulations from the best two formulations were finalized, that is, ITC1 and ITC4 which shows the best result of viscosity, irritancy test, tube extrudability, spreadability, acid value and drug content as the best formulation among all the formulation.

It was concluded that Antifungal topical cream of Itraconazole proved better alternate than oral preparation and improve patient compliance, ease of administration, local bioavailability, and better proves for fungal infected patients.