Review on Formulation and Evaluation of Herbal gel of Moringa oleifera and Aloe vera for management of Acne

Acne vulgaris is a common chronic inflammatory skin disorder that primarily affects the pilosebaceous units, resulting from excess sebum production, follicular hyperkeratinization, bacterial colonization, and inflammation. Conventional treatments often cause side effects and drug resistance, leading to interest in natural alternatives. This review focuses on the potential of Moringa oleifera and Aloe vera in acne management through topical drug delivery systems (TDDS). Moringa oleifera possesses potent antimicrobial, anti-inflammatory, antioxidant, and antidiabetic properties due to its rich phytoconstituents, including niazimicin, quercetin, and isothiocyanates. Similarly, Aloe vera contains acemannan, vitamins, and polyphenols that provide moisturizing, woundhealing, and antimicrobial benefits. TDDS offers site-specific drug release, enhanced patient compliance, and minimized systemic side effects, making it a promising approach for acne therapy. The combination of Moringa oleifera and Aloe vera in topical formulations may enhance therapeutic efficacy against acne-causing bacteria such as Propionibacterium acnes and Staphylococcus aureus. Further preclinical and clinical studies are necessary to validate their safety, stability, and long-term effectiveness. This herbal-based TDDS could represent an efficient, eco-friendly, and patient-acceptable alternative for acne treatment.