The Potentials of Dehydroepiandrosterone (DHEA) in Skin ageing process.

Ageing and hormones are inter-related terms playing crucial role in human's life. Dehydroepiandrosterone, commonly known DHEA, is among those hormones which directly interfere with the ageing process and its effects is remarkably visible. The role of DHEA in fighting against the signs of aging have been tested for a long time. Recent researches in the field of hormones and steroids has provided the researcher with new insights to investigate the potentials of DHEA and its sulfate esters in the field of skin aging complications. DHEA, which is an adrenal cortex hormone act as mediator in various biochemical pathways, essentially required for maintaining the homeostasis of the body. The present aim of this review is to focus on the role of DHEA and its sulfate esters in skin aging process and in its related disorders. The review also highlights different delivery systems available for targeting this drug to the desired site of action for better therapeutic activity.