Evaluation study of nasal drug delivery system using spray drying technique

In the present research work it has been studied the various evaluation parameters for the nasal drug delivery system using spray drying technique. The bulk density was mainly influenced by the solid fraction of the dispersion prepared prior to freeze-drying. The bulk density of the powder formulations had no influence on the nasal bioavailability of insulin in rabbits. From this study, it was concluded that the procedure for preparation of the nasal powder formulations was a robust production method. In the present study it has been demonstrated that the selection of an appropriate delivery system is a critical issue in the development of nasal powder formulations.