The present investigation was aimed at evaluating the anticancerpotential of the alcohol and aqueous extracts of leaf of Ophiorrhiza mungos L. on DAL in mice. Animals were inoculated with DAL cells (106 cells/mouse, i.p.) The extracts wereadministered at doses 400 and 800 mg/kg p.o. All the groups except the normal control received DAL cells. The parameters estimated were: Cancer cell count, Packed Cell Volume (PCV), Tumor mass, Increase in Life Span (ILS), Hematological parameters-RBC count, WBC count. HPTLC profiles for Camptothecinin the extracts were also obtained. Following, inoculation with DAL cells, there was profound proliferation of tumor cells in peritoneal cavity of animals which was significantly normalized by the extracts. Significant (p<0.001) changes were observed in tumor and haematological parameters.
Ophiorrhiza Mungos, Dalton's Ascitic Lymphoma, Camptothecin
